**Tumor Necrosis Factor - a cytokine, alerter of the immune system.** Tumor Necrosis Factor (TNF) is a signaling protein (a cytokine) in the immune system responsible for mounting an inflammatory response. It’s interacts with two receptors: 1. TNFR1 - pro-inflammation, promotes cell death 2. TNFR2 - anti-inflammation, promotes wound healing **Suppression of TNFR1** is important in the treatment of autoimmune diseases, like [[Ankylosing Spondylitis]]. That’s what the [[Biologics]] are doing. That’s why those drugs also lower your body’s ability to fight off other infections, because they dampen the pro-inflammation TNFR1 receptor activation. **** # More ## Source [Tumor necrosis factor - Wikipedia](https://en.wikipedia.org/wiki/Tumor_necrosis_factor) ## Related - [[Biologics]] - [[Anti-inflammatory Drugs]]